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Thursday / December 12.
HomeminewsAir Pollution and Glaucoma: A “Striking Correlation”

Air Pollution and Glaucoma: A “Striking Correlation”

Air pollution may be a modifiable risk factor for glaucoma, according to researchers from UCL Institute of Ophthalmology and Moorfields Eye Hospital.

Their study found that people living in areas with higher amounts of fine particulate matter pollution were at least 6% more likely to report having glaucoma than those in the least-polluted areas, according to the findings published in Investigative Ophthalmology & Visual Science.

people in the most-polluted 25% of areas were 18% more likely to report having glaucoma than those in the least-polluted quartile, and they were also significantly more likely to have a thinner retin

This study adds to previous evidence that people in urban areas are 50% more likely to have glaucoma than those in rural areas, suggesting now that air pollution may be a key contributor to that pattern.

“We have found yet another reason why air pollution should be addressed as a public health priority, and that avoiding sources of air pollution could be worthwhile for eye health alongside other health concerns,” said the study’s lead author, Professor Paul Foster (UCL Institute of Ophthalmology and Moorfields Eye Hospital).

“While we cannot confirm yet that the association is causal, we hope to continue our research to determine whether air pollution does indeed cause glaucoma, and to find out if there are any avoidance strategies that could help people reduce their exposure to air pollution to mitigate the health risks.”

“Most risk factors for glaucoma are out of our control, such as older age or genetics. It’s promising that we may have now identified a second risk factor for glaucoma, after eye pressure, that can be modified by lifestyle, treatment or policy changes,” added Professor Foster.

The findings were based on 111,370 participants of the UK Biobank study cohort, who underwent eye tests from 2006 to 2010 at sites across Britain. The participants were asked whether they had glaucoma, and they underwent ocular testing to measure intraocular pressure, and spectral-domain optical coherence tomography imaging.

The participants’ data was linked to air pollution measures for their home addresses, from the Small Area Health Statistics Unit, with the researchers focusing on fine particulate matter (equal or less than 2.5 micrometres in diameter, or PM2.5).

The research team found that people in the most-polluted 25% of areas were 18% more likely to report having glaucoma than those in the least-polluted quartile, and they were also significantly more likely to have a thinner retina, one of the changes typical of glaucoma progression. Eye pressure was not associated with air pollution, which the researchers say suggests that air pollution may affect glaucoma risk through a different mechanism.

“Air pollution may be contributing to glaucoma due to the constriction of blood vessels, which ties into air pollution’s links to an increased risk of heart problems. Another possibility is that particulates may have a direct toxic effect damaging the nervous system and contributing to inflammation,” said the study’s first author, Dr Sharon Chua (UCL Institute of Ophthalmology and Moorfields Eye Hospital).

Air pollution has been implicated in elevated risk of pulmonary and cardiovascular disease as well as brain conditions such as Alzheimer’s disease, Parkinson’s disease and stroke. Particulate matter exposure is one of the strongest predictors of mortality among air pollutants.

“We found a striking correlation between particulate matter exposure and glaucoma. Given that this was in the UK, which has relatively low particulate matter pollution on the global scale, glaucoma may be even more strongly impacted by air pollution elsewhere in the world. And as we did not include indoor air pollution and workplace exposure in our analysis, the real effect may be even greater,” said Professor Foster.

Co-principal investigator of the study, Mr Praveen Patel (NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology), added, “Our study shows the potential of new retinal imaging techniques, to identify disease and to understand how diseases develop so that we can improve health care and find new ways to prevent blindness.”

The study was conducted by researchers at UCL, Moorfields Eye Hospital, Cardiff University and Topcon Healthcare Solutions, and supported by Moorfields Eye Charity, the NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, the Alcon Research Institute, and the International Glaucoma Association.